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-synuclein, that's a major ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) strain, suggest that dysfunction of the intracellular proteinase programs, like ubiquitin-proteasome process or lysosomal technique, which eliminates unnecessary poisonous pro
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